The two condos we own are upstairs units with the best white water views I've seen this close to downtown.
If La Jolla offered this kind of view for VRBO (they really don't), then you'd expect to pay 3X's the price. If you're thinking along the lines of Mission Beach, then think again, the traffic will hinder all your summer plans (same thing with La Jolla traffic!).
Ocean Beach is a gentrified hippie community and check's all the boxes for proximity to the Zoo, Seaworld, Downtown, the Airport, etc, as well as providing this incredible proximity to the water and semi-private ocean cove.