Downtown San Francisco houses

Enjoy more privacy and space when you choose one of the 495 holiday home rentals in Downtown San Francisco. Base yourself in this neighbourhood and you’ll be within easy reach of exciting attractions like Pier 39, Alcatraz Island and University of San Francisco.

Your ideal holiday home rental in Downtown San Francisco is waiting to be discovered, with prices ranging from wallet-conscious stays to more high-end properties. Enter your trip details to compare, ensuring you find the right place for you and your guests.

The best time depends on what you prefer. March is the most popular time of year to stay in a Downtown San Francisco holiday home rental, but if you’d like to get away from the crowds, travel in the shoulder or low season.

There’s only one thing better than spending your time away in one of our Downtown San Francisco holiday home rentals — staying somewhere with stunning views. Scroll through our options to find a house with the amenities you need and the outlooks that’ll make your trip even more amazing. Sort your results by “Recommended” or “Guest rating” and see what’s available.

Browse our weekend rentals and look forward to an unforgettable few days away. Our tips for booking your perfect house in Downtown San Francisco? Be flexible when searching and modify your travel dates until you find the holiday home rental that suits your style.

Use our handy filter tool to browse pet-friendly holiday home rentals in Downtown San Francisco. To discover a house rental that features perks such as an enclosed outdoor space or pet bedding, just check the box marked “Pets allowed.”

Pier 39, Alcatraz Island and Palace of Fine Arts are a few of the top things to see around Downtown San Francisco with the family. If you’re thinking about staying in this popular neighbourhood, we’ll help you find a holiday home rental where you can share treasured moments with the ones you love.

When you choose a Vrbo holiday home rental, the only people you have to share your living space with are whoever you bring with you. It’ll only be you, your closest companions and the whole place for your exclusive use. Plus, when you become a member of One Key™ rewards programme, you can earn and spend OneKeyCash™* on eligible bookings on Vrbo. Also, our flexible cancellation policies also mean you can book your rental house with peace of mind if you need to change your plans. *OneKeyCash disclaimer - OneKeyCash is not redeemable for cash and can only be used on Vrbo.