Southern Illinois house rentals

Choose from 1,208 vacation home rentals around Southern Illinois. Take your loved ones on a fun-filled trip to Red Bud or discover other vibrant cities like Golconda and Goreville. Wherever your travels take you, we’ve got your perfect stay.

Prices vary depending on season, length of stay and property location, so enter your vacation details to browse what’s available. Whatever your plans or budget, Vrbo has vacation home rentals in Southern Illinois for every kind of guest.

August is when the majority of Vrbo guests book a vacation home rental in Southern Illinois. Expect average temperatures of between 66ºF (19ºC) and 86ºF (30ºC) if you travel during this month.

Houses with views of historic areas are just an example of the kinds of vacation home rentals available in Southern Illinois. Whatever scenery you want to gaze out at, we’ve got stays that’ll give you views worth writing home about.

Some of Vrbo’s vacation houses are available for weekend rental, making them ideal for impulsive getaways. Enter your preferred travel dates to check out the availability. You may need to switch up the dates and be flexible with your travel plans to find the right vacation home rental in Southern Illinois.

Don’t worry about leaving your best buddy at home with 95 pet-friendly vacation home rentals in Southern Illinois. We know how important your furry companions are to you, which is why our filters make it a breeze to find only those houses that can accommodate everyone in your family.

Whether you like exploring new places or relaxing in your vacation home rental, research is key when finding things to do in Southern Illinois. First time visiting this destination? Keep your itinerary flexible for those impromptu adventures.

When you stay in a Vrbo vacation home rental, the only people you have to share your space with are those you bring along. It’ll only be you, family or friends and the entire property to yourselves. Plus, when you sign up to our One Key™ rewards program, you can earn and spend OneKeyCash™* on all eligible bookings on Vrbo, Expedia and Hotels.com. Additionally, our flexible cancellation policies also mean you can book your rental house with peace of mind if your plans change. *OneKeyCash disclaimer - OneKeyCash is not redeemable for cash and can only be used on Hotels.com, Expedia and Vrbo.