Isle of Palms houses

Pick one of our 971 vacation home rentals in Isle of Palms and you’ll have a perfect base for your next trip. Yacht Harbor Court, Seaside Farms and Sandcrab are some of the city’s most sought-after neighborhoods.

Where you stay, when you want to travel and your trip length will determine how much you pay for a vacation home rental in Isle of Palms. Key in your travel details on Vrbo to compare properties and then choose the right one for you.

Vrbo makes it easy to book your vacation home rental in Isle of Palms whenever you decide to go. Start by considering the weather conditions for the month you’re thinking of visiting. Going in the high season? Book early to get the best availability.

Vrbo has some awesome vacation home rentals in Isle of Palms, including houses with beach views. Before and after seeing the sights, chill out and stare at scenes that are their own attraction.

Some of our vacation houses can be rented just for the weekend, making them ideal for spontaneous getaways. Enter your desired travel dates to view the availability. You may need to switch up the dates and be flexible with your plans to find the right vacation home rental in Isle of Palms.

There are 21 vacation home rentals that allow pets in Isle of Palms, so your furry friend won’t miss out on the excitement! Use our filter tool to look for pet-friendly houses that come with perks like dogs beds and free treats for them, and a bunch of cozy conveniences for you.

It’s no surprise why many families love Isle of Palms, with cool attractions like USS Yorktown, Charleston City Market and Waterfront Park to explore. Check out this destination’s wonders together and then return to the comforts of your vacation home rental.

First-rate customer support from the moment you book until after your trip is one of the many reasons to choose us for your upcoming vacation home rental. We also offer properties that go beyond the conventional hotel room — think houses in amazing locations, whether that’s by the beach or along a lakeshore. And with flexible cancellation policies and benefits like payment protection, we make traveling easy.