
Daufuskie Island houses
We found 67 houses — enter your dates for availability
Explore Daufuskie Island house rentals
The Evan Cottage
Sleeps 4 · 1 bedroom · 1 bathroom
9.69.6 out of 10
Exceptionalexceptional
169 reviews(169 reviews)
Enjoy an outstanding safe ocean rental on a sparsely populated island
Sleeps 12 · 6 bedrooms · 6 bathrooms
9.89.8 out of 10
Exceptionalexceptional
42 reviews(42 reviews)
Villa 2 BR 2 Bath - cart included with booking!
Sleeps 6 · 2 bedrooms · 2 bathrooms
1010 out of 10
Exceptionalexceptional
61 reviews(61 reviews)
Daufuskie Island Getaway, 2 Bedroom, 2 Bath, Take a break from it ALL
Sleeps 6 · 2 bedrooms · 2 bathrooms
9.89.8 out of 10
Exceptionalexceptional
56 reviews(56 reviews)
BOOK NOW for 2025! New Pricing!
Sleeps 18 · 5 bedrooms · 5 bathrooms
9.89.8 out of 10
Exceptionalexceptional
62 reviews(62 reviews)
Waterfront Home with Dock - Sleeps 14
Sleeps 14 · 7 bedrooms · 6 bathrooms
9.29.2 out of 10
Wonderfulwonderful
96 reviews(96 reviews)
Top rated house rentals - Daufuskie Island
Week stay in March
1010 out of 10
Exceptionalexceptional
66 reviews(66 reviews)
Find spaces that suit your style
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- Peace of mindOur Book with Confidence guarantee gives you 24/7 support
- More quality timeFrom booking to staying, the whole process is simple and enjoyable
- All the privacy of homeEnjoy full kitchens, laundry, pools, yards and more
- More for lessMore space, more privacy, more amenities — more value
Frequently asked questions
Are there any vacation home rentals in Daufuskie Island?
Take your pick of 67 vacation home rentals in Daufuskie Island that have more space, privacy, value and amenities compared to a hotel room. Browse houses in popular neighborhoods such as Melrose on the Beach, South Beach and Bald Eagle West.
How much does it cost to stay in a vacation rental house in Daufuskie Island?
Prices vary depending on length of stay, season and property location, so enter your travel details to discover what’s available. No matter your budget or plans, Vrbo has vacation home rentals in Daufuskie Island suited to every type of guest.
When is the best time to rent a vacation house in Daufuskie Island?
First, consider if you prefer the bustle of high season or the more tranquil vibe of low season. Also think about factors like the weather and what you want to do in Daufuskie Island. Whenever you go, there’ll be a vacation home rental with your name on it.
Where can I rent a Daufuskie Island vacation house with great views?
Use the “Location” filter to find a vacation home rental with the views you’d love to wake up to. Begin by entering the dates you want to book your house in Daufuskie Island, then narrow your search based on the type of area you’d prefer to stay in.
Does Daufuskie Island have any weekend house rentals?
Some of Vrbo’s vacation houses are available for weekend rental, making them perfect for spur-of-the-moment getaways. Enter your preferred travel dates to check out the availability. You may need to play around with dates and be flexible with your travel plans to find the best vacation home rental in Daufuskie Island.
Are there any pet-friendly house rentals in Daufuskie Island?
Share your next adventure with your best friend at one of our six pet-friendly vacation home rentals in Daufuskie Island. These stays come with perks that’ll make your pup feel at home, such as a fenced-in yard. Just select the “Pets allowed” filter to book a house that has space for every beloved member of your family.
What are the top things to do in Daufuskie Island?
There’s a whole lot to discover with you and your kids in Daufuskie Island besides only enjoying the conveniences and comforts of your vacation home rental. Don’t miss leading attractions like Tybee Island Beach and Coligny Beach. Want some more ideas? North Beach deserves a place on your Daufuskie Island must-see list.
Why should I book my vacation rental house with Vrbo?
From houses in quiet countryside areas to those located downtown, Vrbo has a wide variety of vacation home rentals to select from. One of the many great reasons to book with us? You won’t have to share your space with the owner or anyone else. And with flexible cancellation policies and support throughout your trip, we’ll ensure everything goes to plan.