Vacation rentals near Edisto Island Serpentarium
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Discover a selection of private vacation rentals close to Edisto Island Serpentarium that can be your home away from home. Whether you’re traveling with friends, family, or even pets, vacation rentals have the best amenities for hanging out with the people that matter most, which might include cable TV and a washer and dryer. No matter what you're looking for, you'll be able to choose a rental to meet everyone's needs, including accessible or non-smoking choices.
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Find the best place to stay - Edisto Island Serpentarium
2025 VRBO Vacation Rental of the Year! Pool, Hot Tub & Deep Water Dock
Sleeps 12 · 5 bedrooms · 4+ bathrooms
10 out of 10
exceptional
(14 reviews)
Top rated rentals - Edisto Island Serpentarium
ladies beach retreat
10 out of 10
exceptional
(143 reviews)
Peace of mindOur Book with Confidence guarantee gives you 24/7 support
More quality timeFrom booking to staying, the whole process is simple and enjoyable
All the privacy of homeEnjoy full kitchens, laundry, pools, yards and more
More for lessMore space, more privacy, more amenities — more value