South Central Houston vacation rentals
We found 1,924 vacation rentals — enter your dates for availability
Select from 597 houses, 450 apartments, and other vacation rentals to find the perfect place for your stay in South Central Houston. Whether you’re staying in a vacation home with a group or just with your pet, you'll have the best amenities for spending time at your home away from home, which might include a fireplace and a washer and dryer. Whatever you're looking for, you're sure to find a rental for everyone's needs, including accessible or non-smoking choices.
Find spaces that suit your style
House
Condo/Apartment
Find properties near top attractions in South Central Houston
Map Attractions
Find the best place to stay - South Central Houston

Huge 4-Bed House, Walk to Medical Center/MD Anderson/NRG/Rice, Spa, Parking
Sleeps 12 · 4 bedrooms · 3 bathrooms
8.0 out of 10
very good
(3 reviews)
Top rated rentals - South Central Houston

Great home!
10 out of 10
exceptional
(15 reviews)
- Peace of mindOur Book with Confidence guarantee gives you 24/7 support
- More quality timeFrom booking to staying, the whole process is simple and enjoyable
- All the privacy of homeEnjoy full kitchens, laundry, pools, yards and more
- More for lessMore space, more privacy, more amenities — more value